- Rødland et al 2021, Differential Effects of Combined ATR/WEE1 Inhibition in Cancer Cells, Cancers. Available here
- Hauge et al 2021, Expanding roles of cell cycle checkpoint inhibitors in radiation oncology, Int.J. Rad.Biol. Available here
- M. Temelie, R. Talpur, M. Dominguez-Prieto, A.D. Silva, C. Cenusa, L. Craciun, D.I. Savu D.I., N. Moisoi, Impaired integrated stress response and mitochondrial integrity modulate genotoxic stress impact and lower the threshold for immune signalling, Int. J. Mol. Sci. 24(6), 2023, 5891 Available here
- Rødland, G.E.; Temelie, M.; Eek Mariampillai, A.; Hauge, S.; Gilbert, A.; Chevalier, F.; Savu, D.I.; Syljuåsen, R.G., Potential Benefits of Combining Proton or Carbon Ion Therapy with DNA Damage Repair Inhibitors, Cells 13(12) (2024) 1058 Available here
Submitted papers
- Fidel, D. Serafin, C. Zagrean-Tuza, M. Suditu, R. C. Popescu, M. Bacalum, D. Negut, S. Vasilca1,6,8, A. Hanganu, O. Tesileanu, I.C. Chiricuta, A. Sadet, M.A. Voda, and P.R. Vasos, Magnetic resonance biomarkers for timely diagnostic of radiation dose-rate effects, submitted to Sci Rep 2023 Available here
Submitted joint papers
- Gro Elise Rødland, Mihaela Temelie, Ana Maria Serban, Adrian Eek Mariampillai, Nina Frederike Jeppesen Edin, Eirik Malinen, Antoine Gilbert, François Chevalier, Diana I. Savu, Randi G. Syljuåsen, Interferon signaling is enhanced by ATR inhibition in glioblastoma cells irradiated with X-rays, protons or carbon ions – submitted to Radiotherapy & Oncology 2024 Available here
- Mihaela Temelie, Mihaela Tudor, Antoine Gilbert, Gro Elise Rødland, Daniela Stroe, Randi G. Syljuåsen, François Chevalier, Diana I. Savu, ATM and ATR inhibitors induce radiosensitization in glioblastoma cells in a LET dependent manner - submitted to Neoplasia 2024.
- Mihaela Temelie, Ana-Maria Serban, Daniela Stroe, Gro Elise Rødland, Nicoleta Moisoi, Diana Iulia Savu, Glioblastoma-microglia crosstalk modulate the cellular response to treatment with X-ray and DNA-damage repair inhibitors - submitted to Oncoimmunology 2024.
Joint papers in preparation
- Radiosensitization effects induced in tumor cells by the adenosine kinase inhibitor 5-iodotubercidin (original research paper)
- Integrative multi-omics approach to targeted therapy for glioblastoma (original research paper)
Patents
- Roxana Cristina Popescu, Diana Iulia Savu, A. Vodă, P. Vasos, Mihaela Temelie, Ioana Fidel, Diana Serafin, Procedure to determine metabolic biomarkers by nuclear magnetic resonance in human glioblastoma cells following a combined treatment with inhibitors of DNA repair proteins and ionizing radiation, A/00192/19.04.2024 / 2024
Conference-poster presentations
- Simona-Cristina Anghelina, Mihaela Temelie, Liviu Crăciun, Diana Savu, “Investigating proton irradiation effects on glioblastoma cell lines ” Ninth International Conference on Radiation in Various Fields of Research, 14-18 June 2021, Herceg Novi, Montenegro Abstract available here
- Mihaela Temelie, Gro Elise Rødland, Randi G. Syljuåsen, Diana I. Savu, The ATM and CHK1 inhibitors sensitize the glioblastoma cells to proton radiation, The 46th Annual Meeting of the European Radiation Research Society, 26-30 November 2021, Caen, France
- R.C. Popescu, W. Doerr and D. Savu, Improved cytotoxic effects of ionizing radiation in radioresistant tumor models using drug delivery nano-systems, ERRS 2022 - 47th Annual Meeting of the European Radiation Research Society, September 21st - 24th 2022, Catania, Italy
- Mihaela Temelie, Ana Maria Serban, Gro Elise Rødland, Randi G. Syljuåsen, Diana Savu Radiosensitizing effect of some DNA repair inhibitors on the glioblastoma cells, ERPW 2022, 9-14 October 2022, Estoril, Portugal
- Christian Naucke, Gro Elise Rødland, Sissel Hauge, Trond Stokke, Randi G. Syljuåsen. A flow cytometry-based large-scale screen to identify compounds that inhibit DNA repair after radiation. ESTRO 2022, Copenhagen, 6-10 May, 2022
- Diana I. Savu, Gro Elise Rødland, Mihaela Temelie, Ana-Maria Șerban, Adrian Eek Mariampillai, Nina Frederike Jeppesen Edin, Eirik Malinen, Antoine Gilbert, François Chevalier, Randi G. Syljuåsen, ATR kinase inhibitor augments IFN signaling following proton and carbon ion irradiation, ICRR 2023, Montreal, Canada, August 27-30, 2023
- Mihaela Temelie; Mihaela Tudor; Ana-Maria Serban; Gro Elise Rødland; Daniela Stroe; Antoine Gilbert; Francois Chevalier; Randi Syljuåsen; and Diana Savu, Glioblastoma and glioblastoma stem-like cancer cells radiosensitization to X-ray and carbon ions using ATM and ATR inhibitors, ICRR 2023, Montreal, Canada, August 27-30, 2023
- Ana-Maria-Adriana Șerban, Mihaela Temelie, Gro Elise Rødland, Antoine Gilbert, François Chevalier, Randi Syljuåsen, Diana-Iulia Savu, Radiosensitizing effect of ATM and ATR kinase inhibitors on glioblastoma, International Conference on Radiation Applications (RAP 2023), Anavyssos, Greece, May 29 - June 2, 2023
- Gro Elise Rødland, Mihaela Temelie, Ana-Maria Șerban, Adrian Eek Mariampillai, Nina Frederike Jeppesen Edin, Eirik Malinen, Antoine Gilbert, François Chevalier, Diana Iulia Savu, Randi G. Syljuåsen, "IFN signaling after proton and carbon ion irradiation is enhanced by ATR inhibition". 16th bis International Wolfsberg Meeting on Molecular Radiation Biology/Oncology, Hurdal, Oslo, Norway, June 17-19th, 2023
- Poster presentation, Gro Elise Rødland, Title: "IFN signaling after proton and carbon ion irradiation is enhanced by ATR inhibition". Network in Radiation Oncology (NIRO) Annual Meeting, Gardemoen, Norway, Sept 21st, 2023
- Poster presentation, Gro Elise Rødland, Title: "IFN signaling after proton and carbon ion irradiation is enhanced by ATR inhibition". Science day presentations, Institute for Cancer Research, Oslo University Hospital, Norway, Sept 6th, 2023
Conference-poster presentations
- Roxana Cristina Popescu gave: 2 online presentations (May and December 2021) at Magurele-Bucharest for promoting science and research among the young researchers; Talks title: “Cancer therapy: new efficient solutions”; 1 online presentation at Politehnica University, Bucharest (April 2021); Talk title: “Medical Engineer in Research and Development”
- Gro Elise Rødland gave a presentation of the project at the Department of Radiation Biology seminar series, The Norwegian Radium Hospital OUH (about 40 attendees, Nov 12th): Talk title: “Targeting the DNA-damage response to sensitize glioblastoma cells to x-rays and protons”
- Mihaela Temelie gave a presentation of her results to the Norwegian group on Sept 28th (9 attendees); Talk title: “Ionizing radiation effects on normal and tumoral cellular models of the nervous tissue”
- Randi G. Syljuåsen gave a presentation of the project at the symposium "Pre-clinical research in proton therapy – Dresden & Norway" on March 7, 2022. Talk title: “Protons and DNA-damage-response-targeting therapy”
- Gro Elise Rødland gave a presentation of the project at a half day seminar regarding proton therapy at Dept. Physics, University of Oslo on May 31st, 2022: Talk title: "Targeting the DNA-damage response to sensitize cancer cells to x-rays and protons”
- Randi G. Syljuåsen gave a presentation of the project in a general seminar organized at IFIN-HH, Magurele, Romania (September 29th, 2022); Talk title: “Cell cycle checkpoints and DNA repair after radiation”
- Randi G. Syljuåsen, Title: "Radiation-induced DNA damage response and immune signaling". Institute seminar series, Institute for Cancer Research, Oslo University Hospital, March 15th, 2023
- Gro Elise Rødland, Title: "DNA damage responses in cells irradiated with charged particles". Annual network meeting-Danish network of radiobiology researchers, Odense, Denmark, Nov 13-14, 2023
- R.G. Syljuåsen gave a symposium talk (invited speaker) at the ESTRO 2024 Congress (Glasgow, UK May 3-7, 2024), where she included results from this project. Talk title: "Role of DNA damage checkpoint inhibition in regulating anti-tumor immunity"
Joint papers in preparation
- Diana Savu gave interviews about the project, which were broadcast over radio on October 31, 2022 (PODCAST - Radio România Actualităţi - Lumea de mâine) and November 7, 2022 (Știința 360 - DORADIOS, pași în obținerea de soluții pentru tratarea glioblastomului)
- Randi G. Syljuåsen and Francois Chevalier were also interviewed about the project, the interview being broadcast on radio
- Diana Savu was interviewed about the project, the interview being available on the Research in the spotlight podcast page, as well as on Facebook, Linkedin, X, YouTube and Spotify.